Latest Episodes
Episode 90
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July 29, 2025
90: Sex, APOE-ε4 and TREM2: Who drives tau in medial temporal and neocortex?
Giorgio J et al., Nature Communications - A multi-cohort neuroimaging and genetics study (n=1,354) used PET and causal path modelling to test how sex,...
00:15:57
Episode 89
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July 28, 2025
89: Genetics of Smell and Sex Differences
Förster F et al., Nature Communications - This GWAMA of up to 21,495 European-ancestry participants used the Sniffin' Sticks odour identification test to map...
00:20:28
Episode 88
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July 27, 2025
88: Stable heritability of childhood Type 1 diabetes
Wei Y et al., Nature Communications - A Swedish nationwide register study of 2.93 million children born 1982–2010 found that the heritability of childhood-onset...
00:18:28
Episode 87
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July 26, 2025
87: Tracing Allograft Injury with cfDNA Methylation
Nature Communications - This study used fragment-level, sequence-based DNA methylation of circulating cell-free DNA to map cellular origins of tissue damage after liver transplant....
00:20:20
Episode 86
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July 25, 2025
86: Why Pathogenic Variant Impact Varies: Variant Effects, Polygenic Background, and Epistasis
Nature Communications - A biobank-scale study using UK Biobank and Mount Sinai BioMe exomes examines three genetic contributors to incomplete penetrance and variable severity...
00:19:27
Episode 85
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July 24, 2025
️ 85: Genomic landscape of virus-associated cancers
️ Episode 85: Genomic landscape of virus-associated cancers In this episode of PaperCast Base by Base, we explore the comparative genomic analysis of virus-positive...
00:23:15