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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

51: Finding Hidden mtDNA Diagnoses in Solve-RD

Episode 51

June 21, 2025

51: Finding Hidden mtDNA Diagnoses in Solve-RD

Ratnaike et al et al., The American Journal of Human Genetics - This episode reviews a Solve-RD reanalysis that integrated an mtDNA-focused bioinformatic pipeline...

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00:17:38

50: Translating the Microbiome to the Clinic

Episode 50

June 19, 2025

50: Translating the Microbiome to the Clinic

Porcari S et al., Cell - Perspective reviewing current diagnostic and therapeutic advances in gut microbiome research and outlining the methodological, biological, regulatory, and...

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00:17:57

49: Chitin as a reservoir: DNA adsorption and gene transfer in Vibrio cholerae

Episode 49

June 18, 2025

49: Chitin as a reservoir: DNA adsorption and gene transfer in Vibrio cholerae

Holt JD et al., PNAS - Using microfluidic flow assays and live-cell imaging, the authors show that environmental DNA adsorbs to chitin particles and...

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00:22:59

48: Mainstreaming Clinical Genetic Testing: A Framework for Care

Episode 48

June 16, 2025

48: Mainstreaming Clinical Genetic Testing: A Framework for Care

Mackley MP et al., Genetics in Medicine - A consensus-driven conceptual framework from Canadian genetics experts describing four models for mainstreaming clinical genetic testing...

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00:16:11

47: Encoding and decoding chemokine-GPCR selectivity

Episode 47

June 16, 2025

47: Encoding and decoding chemokine-GPCR selectivity

Kleist AB et al., Cell - A data-driven mapping of how 46 human chemokines and 23 GPCRs encode selective and promiscuous interactions. The team...

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00:22:38

46: How tRNA modifications tune m6A-dependent mRNA decay

Episode 46

June 14, 2025

46: How tRNA modifications tune m6A-dependent mRNA decay

Linder B et al., Cell - This episode explores a pan-epitranscriptomic mechanism showing how m6A in coding sequences slows ribosomal decoding to trigger translation-dependent...

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00:20:34