Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis

Episode 101

•

August 09, 2025

101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis

JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base is...

Play

00:18:25

100: ALMA: Epigenomic diagnosis & prognosis of AML

Episode 100

•

August 08, 2025

100: ALMA: Epigenomic diagnosis & prognosis of AML

Marchi F et al., Nature Communications - This study builds the Acute Leukemia Methylome Atlas (ALMA) from 3,314 patient methylomes and presents three models—ALMA...

Play

00:14:44

99: NXT2: a testis-specific RNA export hub essential for human spermatogenesis

Episode 99

•

August 07, 2025

99: NXT2: a testis-specific RNA export hub essential for human spermatogenesis

Dicke A-K et al., Nature Communications - Proteomics, molecular and genetic analyses identify NXT2 as the predominant NXT protein in the human testis that...

Play

00:14:36

98: Cell Marker Accordion: Interpretable Single-Cell & Spatial Annotation

Episode 98

•

August 06, 2025

98: Cell Marker Accordion: Interpretable Single-Cell & Spatial Annotation

Busarello E et al., Nature Communications - This episode covers the Cell Marker Accordion, an integrated marker database plus R package and Shiny app...

Play

00:19:20

️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial

August 05, 2025

️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial

️ Episode 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial In this episode of PaperCast Base by Base, we explore how integrated whole...

Play

00:21:43

️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease

August 04, 2025

️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease

️ Episode 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease In this episode of PaperCast Base by Base, we explore...

Play

00:16:39