Latest Episodes
Episode 17
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May 13, 2025
17: The structure of human sweetness
Juen Z et al., Cell - This episode examines a cryo-EM study that resolves the human sweet taste receptor (TAS1R2+TAS1R3) bound to two artificial...
00:20:18
Episode 16
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April 25, 2025
16: Advancing equity in human genomics
Arruda AL et al., Cell Genomics - A commentary calling for generation of tissue-specific molecular data across diverse ancestries to improve fine-mapping, causal inference,...
00:15:52
Episode 15
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April 25, 2025
15: The genetic changes that shaped Neandertals, Denisovans, and modern humans
Zeberg H et al., Cell - A review of genetic differences among modern humans, Neandertals, and Denisovans, their functional consequences, and how introgression and...
00:20:07
Episode 14
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April 25, 2025
14: Who Benefits from Large-Scale Genomic Programmes?
Horn R et al., European Journal of Human Genetics - Workshop report assessing the practical benefits and limits of national genomic programmes across societal,...
00:25:44
Episode 13
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April 25, 2025
13: Human de novo mutation rates from a four‑generation pedigree
Nature - A telomere‑to‑telomere, multigenerational study that uses five sequencing technologies to assemble and phase near‑complete diploid genomes from a 28‑member family (CEPH 1463)...
00:19:34
![12: MUTYH's allosteric [4Fe-4S] network](https://episodes.castos.com/6857d0f4a3b5e4-25951952/images/2107599/c1a-p6xp7-47415nxxbjo4-q9r19u.png)
Episode 12
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April 19, 2025
12: MUTYH's allosteric [4Fe-4S] network
Trasviña-Arenas CH et al., Nature Communications - This episode explores a 2025 study that reports the first human MUTYH structure bound to a transition...
00:16:28