Latest Episodes
Episode 69
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July 08, 2025
69: PLK1 overexpression exposes an IGF2BP2 vulnerability
Cunningham C et al., Cell Genomics - This study used orthotopic breast PDX models, pooled and arrayed CRISPR/Cas9 screens, and Direct‑Capture Perturb‑seq to search...
00:16:15
Episode 68
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July 07, 2025
68: Indels Enable One-Step Antiviral Innovation in TRIM5a
Tenthorey JL et al., Cell Genomics - This episode examines a study showing that insertion/deletion mutations (indels) in the v1 loop of the antiviral...
00:16:04
Episode 67
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July 06, 2025
67: M-REGLE: Multimodal AI improves genetic prediction of cardiovascular traits
Zhou Y et al., The American Journal of Human Genetics - This episode explores M-REGLE, a multimodal deep‑learning pipeline that jointly learns representations from...
00:14:47
Episode 66
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July 05, 2025
66: Mainstreaming Clinical Genetic Testing: A Conceptual Framework
Mackley MP et al., Genetics in Medicine - This episode summarizes a consensus-derived framework for mainstreaming clinical genetic testing developed from a Canadian expert...
00:20:02
Episode 65
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July 04, 2025
65: Hidden splice variants in FBN1 — genome sequencing finds Marfan diagnoses
Walker S et al., Genetics in Medicine - This episode reviews a systematic analysis of ultra-rare FBN1 variants in the 100,000 Genomes Project using...
00:18:37
Episode 64
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July 03, 2025
64: Pisces: Multi-modal augmentation for drug combination prediction
Xu H et al., Cell Genomics - This episode covers Pisces, a machine-learning framework that augments sparse drug-pair datasets by creating multiple modality-based views...
00:23:10