Latest Episodes
Episode 75
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July 14, 2025
75: How Metabolism Shapes Enzyme Structures Over 400 Million Years
Lemke O et al., Nature - A deep structural and evolutionary analysis of 11,269 enzyme structures across Saccharomycotina reveals how metabolic context sculpts protein...
00:14:56
Episode 74
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July 13, 2025
74: Benchmarking TCR-epitope predictors with ePytope-TCR
Drost F et al., Cell Genomics - Drost et al. integrated 21 pre-trained sequence-based TCR-epitope predictors into ePytope-TCR and benchmarked them on a viral...
00:20:10
Episode 73
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July 12, 2025
73: Family history and genetics in dementia
König T et al., Genetics in Medicine - A retrospective study of 701 memory clinic patients tested whether stratifying by age at onset and...
00:15:55
Episode 72
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July 11, 2025
72: POC5 ciliopathy: retinal, endocrine and neuromuscular syndrome
Vulto-van Silfhout AT et al., Genetics in Medicine - A cohort study of twelve families shows that bi-allelic loss-of-function variants in POC5 cause a...
00:19:44
Episode 71
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July 10, 2025
71: ELFN1 Deficiency: Mechanisms and Clinical Spectrum
Dore R et al., Genetics in Medicine - This episode reviews a multi-center study that defines ELFN1 deficiency as a recessive neurodevelopmental disorder. The...
00:25:16
Episode 70
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July 09, 2025
70: MSA and ternary-code DNA methylation
Goldberg DC et al., Cell Genomics - This episode examines the methylation screening array (MSA), a compact Infinium BeadChip optimized for trait-associated and cell-type...
00:19:10