Latest Episodes
Episode 119
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August 27, 2025
119: G-quadruplexes, pericentromeres, and B cell genome instability
Waisertreiger I et al., PNAS - This study tests how stabilization of G-quadruplex (G4) DNA by ligands such as pyridostatin (PDS) affects genome stability...
00:18:35
Episode 118
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August 26, 2025
118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B
️ Episode 118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B In this episode of PaperCast Base by Base,...
00:19:11
Episode 117
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August 25, 2025
117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection
Pol III–linked polyadenylation fuels SINE RNA accumulation during infection Music:Enjoy the music based on this article at the end of the episode. DOI:10.1073/pnas.2507186122 Support:Base...
00:16:00
Episode 116
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August 24, 2025
116: Silent but Stalling: A Synonymous mtDNA Variant Shapes CD8+ T Cells
Lareau CA et al., PNAS - Single-cell multiomic profiling identifies a mosaic synonymous mtDNA variant (m.7076A>G) in MT-CO1 that is selectively depleted in CD8+...
00:15:53
Episode 115
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August 24, 2025
115: Neurofibromin, KRAS, and new targets for NF1 tumors
Vasudevan HN et al., PNAS - CRISPRi, transcriptomic and proteomic profiling in peripheral nervous system cell models reveal how NF1 loss rewires Ras signaling,...
00:15:24
Episode 114
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August 22, 2025
114: One-hour extraction-free LAMP HPV test for point-of-care screening
Barra MJ et al et al., Nature Communications (2025) 16:7295 - This study reports development and analytic evaluation of an extraction-free DARQ LAMP assay...
00:16:31