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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

81: Pharmacogenetics in a Large Chinese Cohort

Episode 81

July 20, 2025

81: Pharmacogenetics in a Large Chinese Cohort

Wei C-Y et al et al., Nature Communications - Retrospective analysis of 486,956 Han Chinese from the Taiwan Precision Medicine Initiative evaluated prevalence and...

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00:21:10

80: Genome sequencing predicts outcomes after congenital cardiac surgery

Episode 80

July 19, 2025

80: Genome sequencing predicts outcomes after congenital cardiac surgery

Watkins WS et al et al., Nature Communications - A prospective observational study of 2,253 Pediatric Cardiac Genomics Consortium patients shows that whole-exome sequencing...

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00:16:15

79: Cross-population GWAS and Proteomics Reveal AF Mechanisms and Better Risk Prediction

Episode 79

July 18, 2025

79: Cross-population GWAS and Proteomics Reveal AF Mechanisms and Better Risk Prediction

Nature Communications - A large cross-population GWAS meta-analysis (168,007 AF cases) integrated with proteomic data identifies hundreds of AF loci, implicates cardiac and TGF-β...

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00:17:17

78: Unloading Lipids: TTYH2 Meets APOE

Episode 78

July 17, 2025

78: Unloading Lipids: TTYH2 Meets APOE

Sukalskaia A et al., Nature - This Nature study identifies APOE as an interaction partner of human TTYH2, maps their endosomal colocalization and binding...

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00:14:53

77: REX: a range extender for long-distance enhancer activity

Episode 77

July 16, 2025

77: REX: a range extender for long-distance enhancer activity

Bower G et al., Nature - This paper identifies a conserved cis element, REX, and a [C/T]AATTA homeodomain motif signature that are necessary and...

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00:16:31

️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian

Episode 76

July 15, 2025

️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian

️ Episode 76: Whole-genome Ancestry of an Old Kingdom Egyptian In this episode of PaperCast Base by Base, we explore the first 2× coverage...

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00:13:22