Latest Episodes
Episode 126
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September 03, 2025
126: Smith-Magenis Syndrome: Chromatin Rewiring to Hyperexcitable Neurons
Lee Y et al., The American Journal of Human Genetics - This episode reviews a study using hiPSC-derived 2D cortical neurons and 3D cortical...
00:20:59
Episode 125
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September 02, 2025
125: GP2: A Global Roadmap for Parkinson’s Genetics
Blauwendraat C et al., The American Journal of Human Genetics - This episode reviews a perspective on the Global Parkinson’s Genetics Program (GP2), a...
00:22:46
Episode 124
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September 01, 2025
124: Omnigenic Architecture and Core Genes in Ulcerative Colitis
Ratajczak F et al., The American Journal of Human Genetics - This study uses the Speos graph machine-learning framework on multi-modal molecular networks to...
00:23:47
Episode 123
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August 31, 2025
123: Dominant-negative ATP5F1A variants and uncoupled oxidative phosphorylation
Fielder SM et al et al., EMBO Molecular Medicine - This episode examines a study that identifies de novo heterozygous missense variants in ATP5F1A...
00:18:12
Episode 122
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August 30, 2025
122: Patient stratification reveals the molecular basis of disease co-occurrences
Urda-García B et al., PNAS - This episode discusses a PNAS study that builds disease similarity networks from public RNA-seq data and shows that...
00:19:57
Episode 121
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August 29, 2025
121: G-quadruplexes, BRCA2, and a Helicase Weak Spot
Keahia DL et al., Proceedings of the National Academy of Sciences (PNAS) - This study shows that G-quadruplex (G4) DNA structures are hotspots of...
00:19:02