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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

93: Bovine H5N1 Shows Neurovirulence in Mice

Episode 93

August 01, 2025

93: Bovine H5N1 Shows Neurovirulence in Mice

Tipih T et al., Nature Communications - Comparative mouse study finds a dairy-cow-derived H5N1 clade 2.3.4.4b (genotype B3.13) isolate is highly virulent, producing rapid...

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00:19:01

92: Loss of CFHR5 Function Lowers AMD Risk

Episode 92

July 31, 2025

92: Loss of CFHR5 Function Lowers AMD Risk

Nature Communications - A FinnGen-based genetic and functional study identifies CFHR5 loss-of-function variants as independently protective against age-related macular degeneration and links reduced FHR-5...

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00:16:49

91: Plasma N‑Glycome, Liver Disease & Anti‑inflammatory Proteins

Episode 91

July 30, 2025

91: Plasma N‑Glycome, Liver Disease & Anti‑inflammatory Proteins

Sharapov S et al., Nature Communications - This episode examines a large multi-cohort GWAS of the human plasma N-glycome (N≈10,764) that maps genetic regulation...

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00:17:42

90: Sex, APOE-ε4 and TREM2: Who drives tau in medial temporal and neocortex?

Episode 90

July 29, 2025

90: Sex, APOE-ε4 and TREM2: Who drives tau in medial temporal and neocortex?

Giorgio J et al., Nature Communications - A multi-cohort neuroimaging and genetics study (n=1,354) used PET and causal path modelling to test how sex,...

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00:15:57

89: Genetics of Smell and Sex Differences

Episode 89

July 28, 2025

89: Genetics of Smell and Sex Differences

Förster F et al., Nature Communications - This GWAMA of up to 21,495 European-ancestry participants used the Sniffin' Sticks odour identification test to map...

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00:20:28

88: Stable heritability of childhood Type 1 diabetes

Episode 88

July 27, 2025

88: Stable heritability of childhood Type 1 diabetes

Wei Y et al., Nature Communications - A Swedish nationwide register study of 2.93 million children born 1982–2010 found that the heritability of childhood-onset...

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00:18:28