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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

137: Rethinking RNA-binding proteins: riboregulation beyond the classics

Episode 137

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September 14, 2025

137: Rethinking RNA-binding proteins: riboregulation beyond the classics

Hentze MW et al., Cell - A review that examines the expansion of the RNA-binding proteome, evaluates evidence for many non-canonical RBPs, and highlights...

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00:25:11

136: Gene context drift and RECODR: predicting targets to prevent cancer relapse

Episode 136

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September 13, 2025

136: Gene context drift and RECODR: predicting targets to prevent cancer relapse

Jassim A et al., Cancer Cell - This episode summarizes Jassim et al.'s introduction of RECODR, a graph-embedding pipeline that measures gene co-expression context...

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00:14:48

135: Micronutrients and Modern Human Evolution

Episode 135

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September 12, 2025

135: Micronutrients and Modern Human Evolution

Rees J et al., The American Journal of Human Genetics - Rees et al. analyze signatures of positive selection in 276 genes linked to...

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00:14:26

134: Single-cell view of Barrett's esophagus and EAC

Episode 134

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September 11, 2025

134: Single-cell view of Barrett's esophagus and EAC

Wenzel M et al., Cell Genomics - This episode reviews a single-cell transcriptional atlas comparing Barrett's esophagus, intestinal metaplasia, normal esophagus/gastric samples and esophageal...

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00:15:47

133: Long-read meta-pangenomics links gut genomes to child growth

Episode 133

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September 10, 2025

133: Long-read meta-pangenomics links gut genomes to child growth

Minich JJ et al., Cell - Minich et al. apply PacBio and Oxford Nanopore long‑read metagenomics to generate 986 complete metagenome‑assembled genomes from Malawian...

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00:24:31

132: Transcriptome classifiers predict docetaxel sensitivity in advanced prostate cancer

Episode 132

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September 09, 2025

132: Transcriptome classifiers predict docetaxel sensitivity in advanced prostate cancer

Grist E et al., Cell - Large-scale transcriptome profiling of 1,523 diagnostic prostate tumors from randomized STAMPEDE phase 3 trials linked expression signatures and...

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00:20:35