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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

99: NXT2: a testis-specific RNA export hub essential for human spermatogenesis

Episode 99

August 07, 2025

99: NXT2: a testis-specific RNA export hub essential for human spermatogenesis

Dicke A-K et al., Nature Communications - Proteomics, molecular and genetic analyses identify NXT2 as the predominant NXT protein in the human testis that...

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00:14:36

98: Cell Marker Accordion: Interpretable Single-Cell & Spatial Annotation

Episode 98

August 06, 2025

98: Cell Marker Accordion: Interpretable Single-Cell & Spatial Annotation

Busarello E et al., Nature Communications - This episode covers the Cell Marker Accordion, an integrated marker database plus R package and Shiny app...

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00:19:20

️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial

August 05, 2025

️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial

️ Episode 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial In this episode of PaperCast Base by Base, we explore how integrated whole...

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00:21:43

️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease

August 04, 2025

️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease

️ Episode 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease In this episode of PaperCast Base by Base, we explore...

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00:16:39

95: Mitochondria transfer: biotech strategies and clinical hurdles

Episode 95

August 03, 2025

95: Mitochondria transfer: biotech strategies and clinical hurdles

Kubat GB et al., Nature Communications - This Perspective surveys recent biotechnological advances that enhance mitochondria transfer and transplantation (MTT) — including surface functionalization,...

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00:19:10

94: Intraindividual epigenetic heterogeneity in advanced prostate cancer

Episode 94

August 02, 2025

94: Intraindividual epigenetic heterogeneity in advanced prostate cancer

Mizuno K et al., Nature Communications - Multi-omic profiling (DNA methylation, RNA-seq, H3K27ac and H3K27me3) of 98 metastatic CRPC samples from 35 patients reveals...

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00:20:29