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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

105: When Tumors Go Neutral: Genome-Level Selection and Resistance

Episode 105

August 13, 2025

105: When Tumors Go Neutral: Genome-Level Selection and Resistance

Persi E et al., Nature Communications - This episode unpacks a multi-cohort study showing that tumors evolving toward neutral genome-level selection (dN/dS ≈ 1)...

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00:18:28

104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation

Episode 104

August 12, 2025

104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation

Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation Music:Enjoy the music based on this article at the end of...

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00:16:56

103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery

Episode 103

August 11, 2025

103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery

Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base...

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00:17:56

102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

Episode 102

August 10, 2025

102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Music:Enjoy the music based on this article at the end of the episode....

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00:14:38

101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis

Episode 101

August 09, 2025

101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis

JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base is...

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00:18:25

100: ALMA: Epigenomic diagnosis & prognosis of AML

Episode 100

August 08, 2025

100: ALMA: Epigenomic diagnosis & prognosis of AML

Marchi F et al., Nature Communications - This study builds the Acute Leukemia Methylome Atlas (ALMA) from 3,314 patient methylomes and presents three models—ALMA...

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00:14:44