Latest Episodes
Episode 111
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August 19, 2025
111: HANCOCK: Multimodal Dataset for Precision Oncology in Head and Neck Cancer
Dörrich M et al., Nature Communications - This episode summarizes HANCOCK, a monocentric multimodal dataset of 763 head and neck cancer patients combining demographics,...
00:17:06
Episode 110
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August 18, 2025
110: Rare coding variants implicate STAG1 and ZNF136 in schizophrenia
Chick SL et al et al., Nature Communications - Largest exome-sequencing meta-analysis to date (28,898 cases, 103,041 controls, 3,444 trios) identifies STAG1 and ZNF136...
00:20:31
Episode 109
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August 17, 2025
109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality
️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality In this episode of PaperCast Base by Base, we explore how loss of the RNA...
00:18:10
Episode 108
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August 16, 2025
108: Epigenome Editing Reverses HBG Silencing
Bell HW et al et al., Nature Communications - This study shows that CpG methylation at proximal HBG promoters causally enforces perinatal silencing and...
00:20:53
Episode 107
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August 15, 2025
107: Host genetics of endodontic infections: FinnGen GWAS
Salminen A et al., Nature Communications - A large GWAS in 485,230 FinnGen participants (132,124 cases) identified genetic loci associated with pulpal and apical...
00:19:07
Episode 106
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August 14, 2025
106: Decoding Cortical Transcriptomes: GABAA Subunit Classes and Pharmacotranscriptomics
Ecker C et al., Nature Communications - This episode reviews a study that develops a surface-based, vertex-level framework for genome-wide imaging transcriptomics using spatial...
00:19:25