Latest Episodes
Episode 117
•
August 25, 2025
117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection
Pol III–linked polyadenylation fuels SINE RNA accumulation during infection Music:Enjoy the music based on this article at the end of the episode. DOI:10.1073/pnas.2507186122 Support:Base...
00:16:00
Episode 116
•
August 24, 2025
116: Silent but Stalling: A Synonymous mtDNA Variant Shapes CD8+ T Cells
Lareau CA et al., PNAS - Single-cell multiomic profiling identifies a mosaic synonymous mtDNA variant (m.7076A>G) in MT-CO1 that is selectively depleted in CD8+...
00:15:53
Episode 115
•
August 24, 2025
115: Neurofibromin, KRAS, and new targets for NF1 tumors
Vasudevan HN et al., PNAS - CRISPRi, transcriptomic and proteomic profiling in peripheral nervous system cell models reveal how NF1 loss rewires Ras signaling,...
00:15:24
Episode 114
•
August 22, 2025
114: One-hour extraction-free LAMP HPV test for point-of-care screening
Barra MJ et al et al., Nature Communications (2025) 16:7295 - This study reports development and analytic evaluation of an extraction-free DARQ LAMP assay...
00:16:31
Episode 113
•
August 21, 2025
113: Joint cohort genomics cracks ultra‑rare disease cases
Nadimpalli Kobren S et al., Nature Communications - The Undiagnosed Diseases Network (UDN) applied joint whole‑genome analysis across 4,236 individuals and introduced RaMeDiES, an...
00:22:08
Episode 112
•
August 20, 2025
112: Local Genetic Sex Differences in Quantitative Traits
️ Episode 112: Local Genetic Sex Differences in Quantitative Traits In this episode of PaperCast Base by Base, we explore how genetic differences between...
00:21:16