Latest Episodes
Episode 123
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August 31, 2025
123: Dominant-negative ATP5F1A variants and uncoupled oxidative phosphorylation
Fielder SM et al et al., EMBO Molecular Medicine - This episode examines a study that identifies de novo heterozygous missense variants in ATP5F1A...
00:18:12
Episode 122
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August 30, 2025
122: Patient stratification reveals the molecular basis of disease co-occurrences
Urda-García B et al., PNAS - This episode discusses a PNAS study that builds disease similarity networks from public RNA-seq data and shows that...
00:19:57
Episode 121
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August 29, 2025
121: G-quadruplexes, BRCA2, and a Helicase Weak Spot
Keahia DL et al., Proceedings of the National Academy of Sciences (PNAS) - This study shows that G-quadruplex (G4) DNA structures are hotspots of...
00:19:02
Episode 120
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August 28, 2025
120: When the Clock Breaks: BMAL1 Variants and a Neurodevelopmental Syndrome
Cuddapah VA et al., Proceedings of the National Academy of Sciences (PNAS) - An international series of 10 individuals with ultrarare heterozygous BMAL1 variants...
00:22:30
Episode 119
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August 27, 2025
119: G-quadruplexes, pericentromeres, and B cell genome instability
Waisertreiger I et al., PNAS - This study tests how stabilization of G-quadruplex (G4) DNA by ligands such as pyridostatin (PDS) affects genome stability...
00:18:35
Episode 118
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August 26, 2025
118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B
️ Episode 118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B In this episode of PaperCast Base by Base,...
00:19:11