Latest Episodes
Episode 38
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June 07, 2025
38: Bat ancestors, recombination, and rapid travel: origins of SARS-CoV and SARS-CoV-2
Pekar JE et al., Cell - Recombination-aware, whole-genome analyses of sarbecoviruses show that genomic fragments very closely related to SARS-CoV and SARS-CoV-2 circulated in...
00:20:29
Episode 37
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June 06, 2025
37: Prioritizing missense variants with chemoproteomic-detected amino acids
Palafox MF et al., The American Journal of Human Genetics - This episode explores a multi-omic study showing that mass spectrometry–based chemoproteomic detection of...
00:23:07
Episode 36
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June 06, 2025
36: Bi-allelic POPDC2 variants and a recessive cardiac syndrome
Nicastro M et al., The American Journal of Human Genetics - This episode covers Nicastro et al. (2025), who identify bi-allelic POPDC2 variants in...
00:18:31
Episode 35
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June 06, 2025
35: Tracing CCR5Δ32 through ancient genomes
This episode summarizes a study that genotyped the CCR5Δ32 deletion in ancient and modern human genomes, compared genotyping methods for low‑coverage ancient DNA, reconstructed...
00:18:20
Episode 34
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June 06, 2025
34: Pegtibatinase in Classical Homocystinuria (COMPOSE)
Ficicioglu C et al., Genetics in Medicine (2025) 27, 101456 - Phase 1/2 COMPOSE trial tested subcutaneous pegtibatinase in 24 participants with classical homocystinuria;...
00:22:51
Episode 33
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June 05, 2025
33: Targeting mis-splicing-derived neoantigens in splicing factor mutant leukemias
Kim WJ et al., Cell - This episode examines a study that identifies recurrent neoantigens produced by SRSF2 and ZRSR2 splicing factor mutations in...
00:20:36