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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

Episode 168

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October 15, 2025

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

Baird D et al., Nature Communications - Low circulating miR-190a-5p predicts progression of chronic kidney disease Music:Enjoy the music based on this article at...

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00:19:10

167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution

Episode 167

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October 14, 2025

167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution

Qu Y et al., Cell Genomics - DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution Music:Enjoy the music based on this article at...

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00:21:40

166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments

Episode 166

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October 13, 2025

166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments

Oosterheert W et al., Cell - Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments Music:Enjoy the music based on this article...

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00:13:37

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

Episode 165

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October 12, 2025

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

Schoenle A et al., Trends in Genetics - Protist Genomics: Key to Understanding Eukaryotic Evolution Music:Enjoy the music based on this article at the...

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00:19:24

164: m6A in the coding sequence: linking deposition, translation, and decay

Episode 164

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October 11, 2025

164: m6A in the coding sequence: linking deposition, translation, and decay

Ćorović M et al., Trends in Genetics - m6A in the coding sequence: linking deposition, translation, and decay Music:Enjoy the music based on this...

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00:14:46

163: Animal origins: looping back in time

Episode 163

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October 10, 2025

163: Animal origins: looping back in time

Matar O et al., Trends in Genetics - Animal origins: looping back in time Music:Enjoy the music based on this article at the end...

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00:14:18