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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

Episode 173

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October 20, 2025

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset In this episode of PaperCast Base by Base, we explore a PNAS...

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00:20:12

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

Episode 172

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October 19, 2025

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense In this episode of PaperCast Base by Base, we...

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00:19:44

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

Episode 171

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October 18, 2025

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

Danchuk S et al., Proceedings of the National Academy of Sciences - Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? Music:Enjoy the...

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00:16:14

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

Episode 170

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October 17, 2025

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

Picchetta L et al., The American Journal of Human Genetics - Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans Music:Enjoy the music based...

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00:17:03

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

Episode 169

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October 16, 2025

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

Aslanzadeh V et al., Nature Communications - Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance Music:Enjoy the music based...

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00:21:13

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

Episode 168

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October 15, 2025

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

Baird D et al., Nature Communications - Low circulating miR-190a-5p predicts progression of chronic kidney disease Music:Enjoy the music based on this article at...

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00:19:10