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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

135: Micronutrients and Modern Human Evolution

Episode 135

September 12, 2025

135: Micronutrients and Modern Human Evolution

Rees J et al., The American Journal of Human Genetics - Rees et al. analyze signatures of positive selection in 276 genes linked to...

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00:14:26

134: Single-cell view of Barrett's esophagus and EAC

Episode 134

September 11, 2025

134: Single-cell view of Barrett's esophagus and EAC

Wenzel M et al., Cell Genomics - This episode reviews a single-cell transcriptional atlas comparing Barrett's esophagus, intestinal metaplasia, normal esophagus/gastric samples and esophageal...

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00:15:47

133: Long-read meta-pangenomics links gut genomes to child growth

Episode 133

September 10, 2025

133: Long-read meta-pangenomics links gut genomes to child growth

Minich JJ et al., Cell - Minich et al. apply PacBio and Oxford Nanopore long‑read metagenomics to generate 986 complete metagenome‑assembled genomes from Malawian...

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00:24:31

132: Transcriptome classifiers predict docetaxel sensitivity in advanced prostate cancer

Episode 132

September 09, 2025

132: Transcriptome classifiers predict docetaxel sensitivity in advanced prostate cancer

Grist E et al., Cell - Large-scale transcriptome profiling of 1,523 diagnostic prostate tumors from randomized STAMPEDE phase 3 trials linked expression signatures and...

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00:20:35

131: Cryptic plasmid pBI143: a small element with outsized presence in the human gut

Episode 131

September 08, 2025

131: Cryptic plasmid pBI143: a small element with outsized presence in the human gut

Fogarty EC et al., Cell (187:1206–1222, February 29, 2024) - This episode summarizes Fogarty et al. 2024, which characterizes pBI143, a 2.7 kb cryptic...

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00:17:59

130: Genetics + CRISPR to Map Obesity and Fat Distribution

Episode 130

September 07, 2025

130: Genetics + CRISPR to Map Obesity and Fat Distribution

Baya NA et al., The American Journal of Human Genetics - This episode summarizes a multi-modal study that integrates exome sequencing in 402,375 UK...

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00:20:24