Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

️ 50: The Microbiome for Clinicians — Bridging Research and Practice

Episode 50

June 19, 2025

️ 50: The Microbiome for Clinicians — Bridging Research and Practice

️ Episode 50: The Microbiome for Clinicians — Bridging Research and Practice In this episode of Base by Base, we explore a Perspective article...

Play

00:17:57

49: Chitin as a reservoir: DNA adsorption and gene transfer in Vibrio cholerae

Episode 49

June 18, 2025

49: Chitin as a reservoir: DNA adsorption and gene transfer in Vibrio cholerae

Holt JD et al., PNAS - Using microfluidic flow assays and live-cell imaging, the authors show that environmental DNA adsorbs to chitin particles and...

Play

00:22:59

48: Mainstreaming Clinical Genetic Testing: A Framework for Care

Episode 48

June 16, 2025

48: Mainstreaming Clinical Genetic Testing: A Framework for Care

Mackley MP et al., Genetics in Medicine - A consensus-driven conceptual framework from Canadian genetics experts describing four models for mainstreaming clinical genetic testing...

Play

00:16:11

47: Encoding and decoding chemokine-GPCR selectivity

Episode 47

June 16, 2025

47: Encoding and decoding chemokine-GPCR selectivity

Kleist AB et al., Cell - A data-driven mapping of how 46 human chemokines and 23 GPCRs encode selective and promiscuous interactions. The team...

Play

00:22:38

46: Decoding ZUF y{ntˆmk�t{z

Episode 46

June 14, 2025

46: Decoding ZUF y{ntˆmk�t{z

Linder B et al., Cell - Analysis and experimental characterization of ZUF y{ntˆmk�t{z and related yZUF nomkÞ patterns using assays and comparative Ltr�~o series...

Play

00:20:34

45: RNA-dependent mechanics of nucleolar subcompartments

Episode 45

June 12, 2025

45: RNA-dependent mechanics of nucleolar subcompartments

Cheng HH et al., Proceedings of the National Academy of Sciences (PNAS) - Using micropipette aspiration in Xenopus laevis oocyte nuclei, authors show the...

Play

00:20:53