Latest Episodes
Episode 62
•
July 01, 2025
62: When Origins Fail: Pre-RC Loss and PARP Inhibitor Resistance
Pappas K et al., PNAS - A genome-wide CRISPR screen in Brca2‑deficient murine prostate organoids identifies loss-of-function in DNA prereplication complex genes (CDT1, CDC6,...
00:17:00
Episode 61
•
June 30, 2025
️ 61: Monkeypox on the Frontline — Developing Brazil’s First qPCR Diagnostic Assay
️ Episode 61: Monkeypox on the Frontline — Developing Brazil’s First qPCR Diagnostic Assay In this episode of Base by Base, we trace the...
00:22:43
Episode 60
•
June 30, 2025
60: Epi-PRS: Genomic LLMs and imputed epigenomics boost polygenic prediction
Zeng W et al., PNAS - This paper introduces Epi-PRS, a workflow that uses genomic large language models to impute cell-type-specific epigenomic features from...
00:17:41
Episode 59
•
June 29, 2025
59: Optimizing Engagement in Cancer Genomics
Crossnohere NL et al., Genetics in Medicine - Overview of how the PE-CGS Network defined, implemented, and evaluated strategies to engage participants and communities...
00:22:55
Episode 58
•
June 28, 2025
58: Jo|wo�t{z {q kzo�|w{tn moww� study
Kwozk L��k~t et al., Ioww Moz{ytm� 9. 433<=7. F�r��� 46. 5359 - This article presents analyses of Jo|wo�t{z {q kzo�|w{tn moww� and related tz�o~km�t{z�...
00:22:04
Episode 57
•
June 27, 2025
57: Low rates of genetic testing in Medicaid-enrolled children with ASD and ID
Brown TR et al., Genetics in Medicine - This episode reviews a claims-based study of 241,060 Medicaid-enrolled children (ages 7–17) from 2008–2016 that measured...
00:19:40