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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

Episode 191

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November 07, 2025

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore...

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00:19:17

190: dGCNA and single-cell maps reveal cell-type mechanisms in T2D

Episode 190

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November 06, 2025

190: dGCNA and single-cell maps reveal cell-type mechanisms in T2D

Martínez‑López JA et al et al., Nature Communications - This episode examines a Nature Communications study that introduces differential Gene Coordination Network Analysis (dGCNA)...

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00:15:43

189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

Episode 189

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November 05, 2025

189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

️ Episode 189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms In this episode of PaperCast Base by Base, we explore how...

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00:14:22

188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis

Episode 188

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November 04, 2025

188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis

️ Episode 188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis In this episode of PaperCast Base by Base, we explore how large‑scale mass‑spectrometry...

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00:16:51

187: Gapped scheduling: CRLX101 + olaparib Phase I trial

Episode 187

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November 03, 2025

187: Gapped scheduling: CRLX101 + olaparib Phase I trial

Nature Communications (2025) 16:9457 et al., Nature Communications - Phase I dose-escalation trial combining CRLX101 (nanoparticle camptothecin) with olaparib using a 48-hour gapped schedule...

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00:16:13

186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome

Episode 186

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November 02, 2025

186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome

️ Episode 186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome In this episode of PaperCast Base by Base, we explore a single‑cell RNA‑seq...

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00:15:22