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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

Episode 196

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November 12, 2025

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

Impact of Chromatin Accessibility QTLs Across Immune Contexts Music:Enjoy the music based on this article at the end of the episode. License:This episode is...

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00:16:37

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

Episode 195

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November 11, 2025

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base is independent and ad-free — no sponsors, no...

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00:18:22

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

Episode 194

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November 10, 2025

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

️ Episode 194: Bayesian History of Science: Watson and Crick and the Structure of DNA In this episode of PaperCast Base by Base, we...

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00:14:29

193: SARM1, DNA, and the Death Signal

Episode 193

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November 09, 2025

193: SARM1, DNA, and the Death Signal

️Episode 193: SARM1, DNA, and the Death Signal In this episode of PaperCast Base by Base, we explore how the axon-degenerating enzyme SARM1 acts...

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00:15:00

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

Episode 192

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November 08, 2025

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

️Episode 192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations In this episode of PaperCast Base by Base, we explore how base-pair resolution maps of chromatin...

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00:14:24

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

Episode 191

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November 07, 2025

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore...

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00:19:17