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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

Episode 165

October 12, 2025

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

Schoenle A et al., Trends in Genetics - Protist Genomics: Key to Understanding Eukaryotic Evolution Music:Enjoy the music based on this article at the...

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00:19:24

164: m6A in the coding sequence: linking deposition, translation, and decay

Episode 164

October 11, 2025

164: m6A in the coding sequence: linking deposition, translation, and decay

Ćorović M et al., Trends in Genetics - m6A in the coding sequence: linking deposition, translation, and decay Music:Enjoy the music based on this...

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00:14:46

163: Animal origins: looping back in time

Episode 163

October 10, 2025

163: Animal origins: looping back in time

Matar O et al., Trends in Genetics - Animal origins: looping back in time Music:Enjoy the music based on this article at the end...

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00:14:18

162: Spatial miRNomics: technologies, challenges, and opportunities

Episode 162

October 09, 2025

162: Spatial miRNomics: technologies, challenges, and opportunities

Robles-Remacho A et al., Trends in Genetics - A concise review of emerging methods to map microRNA (miRNA) expression in tissues with spatial context,...

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00:20:15

161: Decoding genomic landscapes of introgression

Episode 161

October 08, 2025

161: Decoding genomic landscapes of introgression

Huang X et al., Trends in Genetics - A concise review of methodological advances for identifying introgressed loci across genomes. The article surveys summary...

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00:20:55

160: Long reads meet single-cell omics

Episode 160

October 07, 2025

160: Long reads meet single-cell omics

Wen L et al., Trends in Genetics - This review surveys the integration of single-molecule long-read sequencing (SMS) with single-cell genomics, epigenomics and transcriptomics,...

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00:15:36