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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

208: ZAK, Collided Ribosomes, and the Stress Switch

Episode 208

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November 24, 2025

208: ZAK, Collided Ribosomes, and the Stress Switch

ZAK, Collided Ribosomes, and the Stress Switch Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09772-8 License:This episode is...

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00:15:55

207: Semantic Design of de novo Genes with Evo

Episode 207

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November 24, 2025

207: Semantic Design of de novo Genes with Evo

Semantic Design of de novo Genes with Evo Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09749-7 License:This episode...

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00:15:05

206: Wild Birds and the North American H5N1 Epizootic

Episode 206

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November 22, 2025

206: Wild Birds and the North American H5N1 Epizootic

Wild Birds and the North American H5N1 Epizootic Music:Enjoy the music based on this article at the end of the episode. License:This episode is...

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00:17:17

205: Ancient RNA Expression Profiles from the Woolly Mammoth

Episode 205

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November 21, 2025

205: Ancient RNA Expression Profiles from the Woolly Mammoth

Ancient RNA Expression Profiles from the Woolly Mammoth Music:Enjoy the music based on this article at the end of the episode. License:This episode is...

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00:17:19

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

Episode 204

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November 20, 2025

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

StealTHY CRISPR: Revealing Hidden Metastasis Regulators Music:Enjoy the music based on this article at the end of the episode. License:CC BY 4.0 International License...

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00:16:39

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

Episode 203

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November 19, 2025

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

Divergent Evolutionary Dynamics of Benign and Malignant Tumors Music:Enjoy the music based on this article at the end of the episode. License:This episode is...

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00:18:14