Latest Episodes
Episode 221
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December 07, 2025
221: Allele-resolved nanopore tour of the human placental methylome
Kindlova M et al., Nat Commun - Using phased long-read nanopore and short-read sequencing across eight trios, the study maps allele-specific DNA methylation and...
00:20:23
Episode 220
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December 06, 2025
220: AML cell states reveal NPM1 immune-evasion subtypes
Lilljebjörn H et al., Nat Commun - Single-cell and bulk sequencing of 120 AML cases reveal two NPM1-mutated subtypes with distinct immune evasion mechanisms...
00:15:48
Episode 219
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December 06, 2025
219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain
Hällqvist J et al., Nature Communications - Targeted multi-region lipidomics with proteomic and mitochondrial data reveals region- and stage-specific lipid alterations in Parkinson’s disease...
00:16:41
Episode 218
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December 04, 2025
218: SIM1 and the multi-ancestry genomics of erectile dysfunction
Bright U et al., Nat Commun - A large multi-ancestry GWAS meta-analysis identifies a dominant SIM1-linked locus and multiple genetic connections between electronic health...
00:19:37
Episode 217
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December 03, 2025
217: Multiscale triads of meiotic crossover patterning
White MA et al., Nature Communications - FFT and inverse-FFT analysis of Zip3/Zip2, Hop1 and Zip1 on yeast pachytene chromosomes reveals two interdigitated tiers...
00:17:47
Episode 216
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December 02, 2025
216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair
Makins K et al., Nature Communications - This episode reviews a study showing that 53BP1-RIF1 and DNA-PKcs have different genetic relationships across blunt end...
00:18:27