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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 24: The Role of the X Chromosome in Complex Trait Genetics — Unraveling Dosage-Compensation Mechanisms

Episode 24

May 18, 2025

️ 24: The Role of the X Chromosome in Complex Trait Genetics — Unraveling Dosage-Compensation Mechanisms

️ Episode 24: The Role of the X Chromosome in Complex Trait Genetics — Unraveling Dosage-Compensation Mechanisms In this installment of Base por Base,...

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00:14:53

️ 23: Evaluating the Return of Additional Findings from the 100,000 Genomes Project — Participant Experiences of Secondary Genomic Findings

Episode 23

May 17, 2025

️ 23: Evaluating the Return of Additional Findings from the 100,000 Genomes Project — Participant Experiences of Secondary Genomic Findings

️ Episode 23: Evaluating the Return of Additional Findings from the 100,000 Genomes Project — Participant Experiences of Secondary Genomic Findings In this episode...

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00:14:12

️ 22: Immune Sensing Unveiled — Ribonuclease Control of Naked Extracellular RNA

Episode 22

May 16, 2025

️ 22: Immune Sensing Unveiled — Ribonuclease Control of Naked Extracellular RNA

️ Episode 22: Immune Sensing Unveiled — Ribonuclease Control of Naked Extracellular RNA In this episode of Base por Base, we explore a landmark...

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00:16:24

️ 21: High-Throughput Variant Discovery — Pooled Prime Editing in Human Cells

Episode 21

May 16, 2025

️ 21: High-Throughput Variant Discovery — Pooled Prime Editing in Human Cells

️ Episode 21: High-Throughput Variant Discovery — Pooled Prime Editing in Human Cells In this episode of Base by Base, we explore a cutting-edge...

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00:17:05

️ 20: Genotype-Specific Chemoprevention with Sulfadoxine-Pyrimethamine

Episode 20

May 16, 2025

️ 20: Genotype-Specific Chemoprevention with Sulfadoxine-Pyrimethamine

️ Episode 20: Genotype-Specific Chemoprevention with Sulfadoxine-Pyrimethamine In this episode of Base by Base, we examine a comprehensive analysis by Mousa et al. (2025)...

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00:15:29

️ 19: Systematic Identification of Promoter and UTR Variants in Rare Disease Diagnostics

Episode 19

May 14, 2025

️ 19: Systematic Identification of Promoter and UTR Variants in Rare Disease Diagnostics

️ Episode 19: Systematic Identification of Promoter and UTR Variants in Rare Disease Diagnostics In this episode of Base by Base, we delve into...

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00:18:18